Fifteen cases of primiparas and their offsprings (fetal cord) were investigated with regard their serum total, free and esterified cholesterol by means of Liherman Buchard reaction. The serum a-and 3-lipoprotein were analyzed by cellulose acetate electrophoresis, acid the serum atherolipid numbers were calculated on the bases of the serum total cholesterol and -,´a- lipoprotein ratio, with the following conclusion.
1. Total, free and esterified cholesterol are 175.9_25. 3, 45. 112.6 and 133.720.6 mg.% in the normal control women, 201.5--29.5, 55.7--1-12.1 and 157. 1-1_26.2 mg.o in the maternal blood, showing hynercholesterolemia in the latter as compared to the former.
2. The serum total, free and esterified cholesterol in the cord blood are 94.520.4, 32.91.5 and 61. 2-LIS. 9 mg. %, showing hvpocholesterolemia as compared to the control women and maternal blood.
3. The serum a, pre-3, 3-lipoprotein and chylomicron are 24.2 -4.2, 17. 3--3.4, 51.54.8 and 6.0-I.6,´-6´ in the normal women, whereas 11.9-2. 1, 22.25.1, 55.73.3 and 3. 11.250o in the maternal serum, 32.4=8.1, 28.5-´-2.4, 25.8 7.0 and 3.10.9i~ in the cord serum, showing hyper-3-lipoproteinemia in the former and hypo-3-lipoproteinemia in the latter.
4. The serum atherolipid number of the normal control women, maternal cord blood are 4. 21=1. 24, S.02=1.42 and 1. 12_0.37, showing hyperlipemia in the former and hypolipemia in latter.
5. The relative ratio of the serum free and esterified cholestrol of both normal control women and maternal blood is about 1 : 3, while that of the fetal blood about 1 : 2.
6. The relative ratices of the serum a-and "-lipoprotein in the control women is about 1 : 2, that of materna blood about 1 : 3 and that of the fetal blood about equal magnitude.
7. The serum esterified cholesterol, a-lipoprotein, (3-/a-lipoprotein ratio and atherolipid number fluctuates are pro ortionally between the maternal and fetal blood, while the serum free, total cholesterol and 3-lipoprotein between the two vary inversely with statistically significant corelations.
8. it is apparent from the above results that the fetal nutritional demand for lipids resulted from hypocholesterolemia and hypo 3-lipoproteinemia seems to be met satisfactorily by maternal hypercholesterolemia and hyper ,S-lipoproteinemia, which seems to pose a significant maternal-infant nutritional relation-ship. A ´:rief c, isc;. ssion vans mace on these conclusion in the light of biochemistry and endocrinology.
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